https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48410 Thu 16 Mar 2023 14:03:44 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7715 10% change in sputum neutrophils using Illumina Humanref-8 expression microarrays. There were 104 genes differentially expressed following the dietary change. Upregulated genes were involved in the innate immune response and included the innate immune receptors TLR2, IL1R2, CD93, the signaling molecules IRAK2, IRAK3, and neutrophil proteases MMP25 and CPD. Downregulated genes included those involved in endogenous antioxidant defenses (GSTA1, GSTA2) and protease inhibition (SLPI, SERPINB3). Altered expression of five genes (TLR2, IRAK2, IL1R2, C20orf114, and SERPINB3) was confirmed using real-time polymerase chain reaction (PCR). These observations suggest that depletion of dietary antioxidants in asthma may result in upregulation of genes involved in the innate immune response. A diet low in antioxidants may be contributing to the development of neutrophilic asthma through activation of the innate immune response.]]> Sat 24 Mar 2018 08:41:39 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:17297 Sat 24 Mar 2018 08:01:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53162 Fri 17 Nov 2023 12:00:09 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47345 Fri 13 Jan 2023 12:16:37 AEDT ]]>